https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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Halfway as a result of his occupation, Cees Dekker reinvented himself. After yrs of hardcore physics, he shifted his concentrate to ‘nanobiology’ within the change of your millennium. A phrase he coined himself, to be a make a difference of fact.
1996, to start with mesoscopic charge density waves units; and to start with electrical measurements on just one steel nanocluster concerning nanoelectrodes
‘It had been just a make a difference of picking up a reserve on mobile biology and starting to browse. I'd come from a environment of extremely-substantial vacuums, cryostats and quantum phenomena, and now I was Doing the job at place temperature with molecular biology kits.
Non-equilibrium folding of personal DNA molecules recaptured around one thousand instances inside a strong state nanopore
2010, made a brand new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into good-point out nanopores
Our research ranges within the biophysics of DNA to artificial cells and further than. You should take a look underneath for the spectrum of our latest initiatives.
What distinguishes biology from chemistry is the fact these components jointly make up a living process. The secret of explained lifestyle, I feel, lies in the interactions, the interplay of Those people molecules. The big problem regarding the origin of everyday living continues to be unanswered. How did we at any time evolve from easy molecules in the incredibly advanced methods we see currently? We do not know. I want to work on These types of big, open inquiries.’
2011, initial in vitro measurements of transport throughout one biomimetic nuclear pore advanced; progress of multiplexed magnetic tweezers cees dekker for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
The rotors harness Vitality from the nanoscale drinking water and ion movement that is created by a static chemical or electrochemical likely gradient within the nanopore, which are recognized through a salt gradient or used voltage, respectively. These artificial nanoengines self-Manage and run autonomously in physiological circumstances, suggesting ways to setting up Power-transducing motors at nanoscale interfaces.
At this time, we also realized that it ought to be doable to implement one semiconducting carbon nanotube for making a transistor — and we established out to make it. We stretched person semiconducting nanotubes across metallic electrodes and made use of the fundamental silicon substrate being a gate electrode, setting up the basic three-terminal structure of the area-impact transistor (Fig.
Case in point (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim with the pore is highlighted in purple, as well as a 3D rendering from the movement with the DNA rod is shown.
2001, discovery of solitary-electron transistors at area temperature based upon nanotubes; realization of to start with logic circuits with carbon nanotube equipment; and discovery of your molecular composition of DNA maintenance enzymes with AFM
Permit’s initially glimpse again in the mean time if you chose to change your emphasis from superconductivity and nanotubes to biology at the conclusion of the nineties.
2004, discovery of latest physics in translocation of DNA via nanopores; first experimental review of ions conduction in nanofluidic channels; very first electrochemistry with individual one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; to start with electrical docking of microtubules on kinesin-coated nanostructures; 1st biophysics characterization from the mechanical Houses of double-stranded RNA; and very first one-molecule examine of DNA translocation by a restriction-modification enzyme.